Computational Modelling

Cooperative-Competitive Whole-Brain Model

A cooperative-competitive Hopf model of brain dynamics for superior realism and subject-specificity.

Mar 11, 2026

Competitive interactions shape mammalian brain network dynamics and computation

We use computational whole-brain modelling across human, macaque, and mouse to show that models with competitive interactions are more realistic, more personalised, more synergistic, and perform better.

Mar 11, 2026

Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains

Across human, macaque, marmoset, and mouse, anaesthesia disrupts integration of information in the mammalian brain, which is restored upon re-awakening by central-thalamic deep-brain stimulation, and reproduced in species-specific computational models.

Jan 28, 2026

Neurotransmission-modulated whole-brain computation captures full task repertoire

Neurotransmission-modulated (NEMO) whole-brain model updates effective connectivity to simulate task states

Jan 27, 2026

Top-down and bottom-up neuroscience: overcoming the clash of research cultures

We outline two different research cultures in neuroscience and the road ahead for overcoming their division.

Jul 21, 2025

Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies

We use network control theory to establish how brain network organization and chemoarchitecture interact to manifest different cognitive topographies, demonstrating the energetic efficiency of the human brain.

Aug 5, 2024

Information decomposition and the informational architecture of the brain

We review how disentangling synergistic and redundant information provides a guiding principle for understanding the informational architecture of the brain and cognition and their evolution.

Apr 1, 2024

Dynamical models to evaluate structure–function relationships in network neuroscience

Computational biophysical models can be used to generate and test mechanistic hypotheses in network neuroscience.

Oct 7, 2022