Predictors of human functional architecture shift from cognitive co-activation toward anatomical-molecular constraints during perturbations of consciousness.
Jun 7, 2026
Across human, macaque, marmoset, and mouse, anaesthesia disrupts integration of information in the mammalian brain, which is restored upon re-awakening by central-thalamic deep-brain stimulation, and reproduced in species-specific computational models.
Jan 28, 2026
Anaesthesia makes human brains less distinguishable from one another, and less distinguishable from the brains of monkeys. We also introduce 'cognitive matching' with NeuroSynth.
Mar 24, 2025
We review how fundamental building blocks of brain function can be identified through the lenses of space, time, and information. Each lens reveals similarities and differences across anaesthesia, coma, and psychedelics, in humans and across different species.
Jul 1, 2024
I outline how combining anaesthesia and neuroimaging holds unique potential for catalysing integrative and translational discovery about consciousness and the brain, across scales and across species.
Apr 8, 2024
We show that anaesthesia collapses the principal gradient of macaque functional connectivity, which is restored upon re-awakening induced by thalamic deep-brain stimulation.
Mar 11, 2024
We identify a core of high-synergy regions whose ability to integrate information is compromised during anaesthesia and in patients with disorders of consciousness.
Jul 18, 2023
We map changes in brain function induced by 10 anaesthetics, psychedelics,a nd cognitive enhancers onto the comprehensive database of human neurotransmitter receptors from Positron Emission Tomography.
Jun 14, 2023
Anaesthesia and disorders of consciousness share disconnection between the default mode network and dopaminergic ventral tegmental area.
Jul 23, 2021
We compare fMRI brain dynamics during anaesthesia and in patients with disorders of consciousness to identify consistent signatures of consciousness.
Oct 10, 2019