Cross-Species Translation

Competitive interactions shape mammalian brain network dynamics and computation

We use computational whole-brain modelling across human, macaque, and mouse to show that models with competitive interactions are more realistic, more personalised, more synergistic, and perform better.

Mar 11, 2026

Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains

Across human, macaque, marmoset, and mouse, anaesthesia disrupts integration of information in the mammalian brain, which is restored upon re-awakening by central-thalamic deep-brain stimulation, and reproduced in species-specific computational models.

Jan 28, 2026

Cognitive cartography of mammalian brains using meta-analysis of AI experts

We use LLMs to perform meta-analyses of human, macaque, and mouse neuroscience literature.

Dec 4, 2025

Benchmarking macaque brain gene expression for horizontal and vertical translation

We benchmark whether gene expression in the macaque brain recapitulate human gene expression, and whether it recapitulates macaque receptor density.

Feb 28, 2025

Unravelling consciousness and brain function through the lens of time, space, and information

We review how fundamental building blocks of brain function can be identified through the lenses of space, time, and information. Each lens reveals similarities and differences across anaesthesia, coma, and psychedelics, in humans and across different species.

Jul 1, 2024

What anaesthesia reveals about human brains and consciousness

I outline how combining anaesthesia and neuroimaging holds unique potential for catalysing integrative and translational discovery about consciousness and the brain, across scales and across species.

Apr 8, 2024

Information decomposition and the informational architecture of the brain

We review how disentangling synergistic and redundant information provides a guiding principle for understanding the informational architecture of the brain and cognition and their evolution.

Apr 1, 2024

Local orchestration of distributed functional patterns supporting loss and restoration of consciousness in the primate brain

We show that anaesthesia collapses the principal gradient of macaque functional connectivity, which is restored upon re-awakening induced by thalamic deep-brain stimulation.

Mar 11, 2024